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Implementation and evaluation of CSI‐localized J cross‐polarization for detection of 31 P magnetic resonance spectra in vivo
Author(s) -
Mancini Laura,
Payne Geoffrey S.,
Leach Martin O.
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20659
Subject(s) - nuclear magnetic resonance , phosphomonoesters , in vivo , chemistry , polarization (electrochemistry) , spectral line , nuclear magnetic resonance spectroscopy , pulse sequence , spectroscopy , resonance (particle physics) , physics , analytical chemistry (journal) , atomic physics , biology , enzyme , microbiology and biotechnology , quantum mechanics , astronomy , inorganic phosphate , chromatography
Double resonance techniques such as INEPT (insensitive nuclei enhanced by polarization transfer) and J CP ( J cross‐polarization) have previously been applied in vitro to enhance the SNR of low‐sensitivity nuclei and detect altered metabolism, for example, with 13 C magnetic resonance spectroscopy (MRS), where the 1 H‐ 13 C scalar couplings are of the order of 130 Hz. The aim of the present study was to investigate the potential advantage of using J CP for the detection of phosphomonoesters (PME) and phosphodiesters (PDE) with 31 P MRS in vivo. These metabolites are involved in membrane metabolism and their concentration is altered in tumors and other pathologies. J CP has been implemented and compared with INEPT and pulse‐and‐acquire in vivo both in unlocalized and in localized spectra in order to select the optimum method for in vivo applications for PME and PDE detection. The results suggest that J CP can give up to 20% more signal in the PME region and up to 70% more signal in the PDE region, with 20 to 70% lower power deposition than INEPT. Such enhancement could be used to reduce the measurement times for equivalent signal‐to‐noise ratios. The J CP sequence is, however, slightly more sensitive than INEPT to RF field inhomogeneities, as predicted from theory. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.