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Transverse relaxation of cells labeled with magnetic nanoparticles
Author(s) -
Ziener C. H.,
Bauer W. R.,
Jakob P. M.
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20634
Subject(s) - radius , spins , relaxation (psychology) , magnetic nanoparticles , nanoparticle , nuclear magnetic resonance , hydrodynamic radius , diffusion , chemistry , molecular physics , physics , materials science , nanotechnology , condensed matter physics , thermodynamics , dynamic light scattering , computer security , computer science , psychology , social psychology
We describe the NMR relaxation properties of magnetically labeled cells. The cells are labeled with magnetic nanoparticles (SPIO, USPIO), which generate susceptibility contrast. The geometry of the labeled cells and the surrounding tissue is considered. We assume that the magnetic nanoparticles accumulate to form a magnetic core of radius R C inside the cell. The correlation time τ, which describes the motion of spins around this core, is analyzed. Using the strong collision approach, explicit expressions are derived for the transverse relaxation rate R 2 *for tissue containing labeled cells as a function of the core radius, the diffusion coefficient, and the concentration of the nanoparticles. The predictions of this model agree well with numerical simulations and experimental data. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.