Premium
Simultaneous water and lipid suppression for in vivo brain spectroscopy in humans
Author(s) -
Smith Mari A.,
Gillen Joseph,
McMahon Michael T.,
Barker Peter B.,
Golay Xavier
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20592
Subject(s) - nuclear magnetic resonance , excitation , spins , waveform , in vivo , bandwidth (computing) , spectroscopy , functional magnetic resonance spectroscopy of the brain , pulse (music) , saturation (graph theory) , physics , offset (computer science) , chemistry , optics , magnetic resonance imaging , materials science , computer science , mathematics , biology , telecommunications , condensed matter physics , medicine , microbiology and biotechnology , radiology , quantum mechanics , voltage , combinatorics , detector , programming language
Abstract A method to achieve simultaneous water and lipid suppression is described. The key feature of the new dual suppression technique is the use of the well‐known hyperbolic secant (HS) waveform as a 90° saturation pulse. Two HS pulses with opposite frequency offsets are employed either sequentially or simultaneously to saturate resonance frequencies corresponding to water and lipid, while leaving the target spins untouched. The excitation bandwidth is controlled by the frequency sweep and offset of each pulse, while varying the pulse length controls the transition bandwidth. An example of the use of the dual saturation method in in vivo magnetic resonance spectroscopic imaging of the human brain is presented. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.