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Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart
Author(s) -
Hu Tom C.C.,
Christian Timothy F.,
Aletras Anthony H.,
Taylor Joni L.,
Koretsky Alan P.,
Arai Andrew E.
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20516
Subject(s) - ischemia , medicine , carnivora , fissipedia , magnetic resonance imaging , coronary occlusion , cardiology , occlusion , contrast (vision) , radiology , artificial intelligence , computer science
The ability of MnCl 2 to enhance canine myocardium and to delineate ischemic areas is demonstrated. A dose–response curve was measured using T 1 weighted images in 11 dogs. MnCl 2 (36, 113, 360, and 3600 μmol) was infused over a period of 3 min. Signal intensity increased linearly with MnCl 2 dose. At 113 μmol (∼10 μmol/kg) the steady‐state increase in intensity averaged 212 ± 34%. No significant physiologic effects due to the infused MnCl 2 were detected except at the highest dose where there was a cardiac depressive effect. Ischemia was induced by occluding the left anterior descending coronary artery in 5 dogs. At an infused dose of 113 μmol, MnCl 2 clearly demarcated the ischemic zone during coronary occlusion. Contrast enhancement in the ischemic zone was less than 30% compared with normal tissue ( P < 0.03). In conclusion, the intracellular contrast agent MnCl 2 enhances the canine heart and shows promise in detecting ischemia at doses that do not cause adverse cardiac effects. Magn Reson Med 54:196–200, 2005. Published 2005 Wiley‐Liss, Inc.