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Continuous artery‐selective spin labeling (CASSL)
Author(s) -
Werner Richard,
Norris David G.,
Alfke Karsten,
Mehdorn H. Maximilian,
Jansen Olav
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20475
Subject(s) - cerebral arteries , arterial spin labeling , artery , imaging phantom , basilar artery , middle cerebral artery , perfusion , posterior communicating artery , carotid arteries , internal carotid artery , nuclear magnetic resonance , medicine , nuclear medicine , physics , radiology , cardiology , ischemia
A new technique for selective spin labeling of individual arteries is presented. It is based on continuous arterial spin labeling (CASL) with an amplitude‐modulated control experiment. Precessionary motion of the labeling gradient about the axis of the artery, combined with an appropriate frequency modulation of the labeling RF pulse, restricts the adiabatic inversion to the desired artery. In phantom studies, it was found that the level of selectivity could be controlled by the sequence parameters, and that the achievable labeling efficiency was at a level of ∼80% compared to a regular, nonselective CASL experiment. In a volunteer study we acquired high‐quality images of the perfusion territories of the internal carotid artery (ICA), the basilar artery (BA), the middle cerebral artery (MCA), and both anterior cerebral arteries (ACAs). The results show the method's flexibility for different geometries and flow velocities. Potential applications include perfusion territory imaging of smaller cerebral arteries, and selective angiography techniques. Magn Reson Med 53:1006–1012, 2005. © 2005 Wiley‐Liss, Inc.