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Simultaneous perfusion and blood‐oxygenation‐level‐dependent measurements using single‐shot interleaved z ‐shim echo‐planar imaging
Author(s) -
Yang Yihong,
Gu Hong,
Silbersweig David A.,
Stern Emily
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20431
Subject(s) - shim (computing) , blood oxygenation , perfusion , oxygenation , cerebral blood flow , perfusion scanning , blood oxygen level dependent , communication noise , blood flow , signal (programming language) , biomedical engineering , single shot , magnetic resonance imaging , nuclear magnetic resonance , functional magnetic resonance imaging , nuclear medicine , computer science , physics , medicine , radiology , optics , cardiology , linguistics , philosophy , erectile dysfunction , programming language
Single‐shot interleaved z ‐shim EPI (SSIZS‐EPI) was extended to a simultaneous perfusion and blood‐oxygenation‐level‐dependent (BOLD) imaging technique that reduces susceptibility‐induced signal loss while preserving rapid image acquisition. Experiments on human brains showed that images acquired with this technique had improved signal‐to‐noise ratio in the inferior prefrontal, meso‐, and lateral–temporal lobes compared with a conventional EPI. Perfusion maps obtained from the SSIZS‐EPI images at resting state illustrated substantial signal recovery in these brain areas. Perfusion and BOLD images collected with a sensorimotor paradigm demonstrated the feasibility of the technique to simultaneously measure cerebral blood flow and blood oxygenation signals associated with brain activation. Functional experiments with a neuropsychiatric paradigm showed increased brain activities in the periamygdalar regions in both perfusion and BOLD maps, consistent with a previous H 2 15 O PET study. The proposed technique, with its advantages of reducing susceptibility artifacts and fast scanning speed, would be useful for obtaining more reliable measurements of functional signals, particularly in the brain regions with field inhomogeneities. Magn Reson Med 53:1207–1211, 2005. Published 2005 Wiley‐Liss, Inc.