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Interindividual reproducibility of glutamate quantification using 1.5‐T proton magnetic resonance spectroscopy
Author(s) -
Jang DongPyo,
Lee JongMin,
Lee Eun,
Park Sangjin,
Kim JaeJin,
Namkoong Kee,
Yoon KangJun,
Kim InYoung,
Kim Sun I.
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20387
Subject(s) - reproducibility , glutamate receptor , nuclear magnetic resonance , proton magnetic resonance , chemistry , nuclear medicine , medicine , physics , chromatography , biochemistry , receptor
Abstract The goal of this study was to measure the interindividual reproducibility of glutamate quantification in 1.5‐T 1 H MRS of human brains. To determine the effective echo time (TE) for glutamate quantification, spectra from a phantom and 12 participants were obtained with TE = 30, 35, 40, and 144 ms (repetition time (TR) = 2000 ms and volume of interest = 4 cm 3 ). The average Cramér–Rao lower bounds for glutamate quantification using LCModel was lowest in two experiments when TE = 40 ms. Twenty‐one subjects participated in experiments that measured interindividual reproducibility of glutamate quantification. Spectra were acquired with TR = 6000 ms and TE = 40 ms. Results showed that the coefficients of variance were 11.0 and 13.1% in the anterior cingulate cortex and insula, respectively. This suggests that glutamate can be reproducibly measured from 1.5‐T 1 H MRS with long TR, effective TE, and the LCModel. Magn Reson Med 53:708–712, 2005. © 2005 Wiley‐Liss, Inc.