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Chemical‐shift‐selective filter for the in vivo detection of J ‐coupled metabolites at 3T
Author(s) -
Schulte Rolf F.,
Trabesinger Andreas H.,
Boesiger Peter
Publication year - 2005
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20362
Subject(s) - in vivo , chemistry , nuclear magnetic resonance , chemical shift , filter (signal processing) , human brain , analytical chemistry (journal) , physics , computer science , chromatography , biology , neuroscience , microbiology and biotechnology , computer vision
A chemical‐shift‐selective filter (CSSF) was applied to the detection of J ‐coupled metabolites in the human brain. This filter is an acquisition‐based technique that requires the chemical shifts (CS's) of different metabolites, but not their whole multiplet structures, to be resolved. The sequence is based on the 2D constant‐time spin‐echo experiment, which yields pure CS spectra in the indirect dimension. Localization is achieved through point‐resolved spectroscopy (PRESS). The method enables unequivocal detection of glutamate and myo ‐inositol, both in vitro and in vivo in the human brain, at 3T. Magn Reson Med 53:275–281, 2005. © 2005 Wiley‐Liss, Inc.