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Quantification of the 31 P metabolite concentration in human skeletal muscle from RARE image intensity
Author(s) -
Greenman Robert L.
Publication year - 2004
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20258
Subject(s) - nuclear magnetic resonance , chemistry , relaxation (psychology) , voxel , image resolution , skeletal muscle , nuclear medicine , human muscle , calf muscle , materials science , anatomy , physics , medicine , optics , radiology , surgery
A method is described for quantifying the cellular phosphorus‐31 ( 31 P) concentration in human skeletal muscle based on RARE (rapid acquisition with relaxation enhancement) image intensities. The 31 P concentrations were calculated using relaxation rates, RF coil spatial characteristics, and RARE signal intensities from foot muscle and an external 31 P standard. 31 P RARE and 1 H T 2 ‐weighted images of the foot muscles in 11 normal subjects were acquired at 3.0 T using a double‐tuned ( 31 P/ 1 H) birdcage coil. 31 P PRESS (point‐resolved spectroscopy) spectra were acquired to verify the measurable 31 P concentrations in a multiecho acquisition. The mean measured concentration was 26.4 ± 3.1 mM (mean ± SD) from RARE signal intensities averaged over the entire imaged foot anatomy and 27.6 ± 4.1 mM for a 3 × 3 pixel region‐of‐interest measurement. The 31 P RARE image acquisition time was 4 min with a 0.55 cm 3 voxel size. These results demonstrate that the 31 P concentration can be accurately measured noninvasively in human muscle from RARE images acquired in short scan times with relatively high spatial resolution. Magn Reson Med 52:1036–1042, 2004. © 2004 Wiley‐Liss, Inc.