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In vivo tumor lactate relaxation measurements by selective multiple‐quantum‐coherence (Sel‐MQC) transfer
Author(s) -
Muruganandham Manickam,
Koutcher Jason A.,
Pizzorno Giuseppe,
He Qiuhong
Publication year - 2004
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20206
Subject(s) - in vivo , t2 relaxation , chemistry , relaxation (psychology) , coherence (philosophical gambling strategy) , nuclear magnetic resonance , physics , biology , neuroscience , magnetic resonance imaging , genetics , medicine , radiology , quantum mechanics
The frequency‐selective multiple‐quantum‐coherence (Sel‐MQC) lactate (Lac) filter offers complete lipid and water suppression in a single scan for robust in vivo detection of tumor Lac, even in the presence of abundant lipids. Conversion of the detected signal into accurate tissue concentrations of Lac requires knowledge of in vivo Lac T 1 and T 2 relaxation times. This work reports modifications to the Sel‐MQC pulse sequence, T 1 ‐ and T 2 ‐Sel‐MQC, that facilitate relaxation measurements of Lac. The T 1 ‐Sel‐MQC sequence combines an inversion prepulse with the Sel‐MQC filter. The T 2 ‐Sel‐MQC sequence incorporates a CH 3 ‐selective 180° pulse during the MQ preparation period to overcome the J‐modulation effects and allow the insertion of variable echo delays. The performance of these sequences was evaluated with the use of phantoms and subcutaneous murine tumor models in vivo. The present approach will allow investigators to correct for the relaxation‐induced Lac signal loss in Sel‐MQC experiments for the quantitative mapping of in vivo tumor Lac distribution. Magn Reson Med 52:902–906, 2004. © 2004 Wiley‐Liss, Inc.