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Localized in vivo human 1 H MRS at very short echo times
Author(s) -
Zhong Kai,
Ernst Thomas
Publication year - 2004
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20201
Subject(s) - nuclear magnetic resonance , in vivo , echo time , human brain , glutamine , nuclear medicine , echo (communications protocol) , chemistry , physics , magnetic resonance imaging , medicine , neuroscience , computer science , radiology , biology , computer network , biochemistry , microbiology and biotechnology , amino acid
A new point‐resolved spectroscopy (PRESS) sequence was developed that allows localized human proton MR spectra to be acquired at echo times (TEs) of 10 ms or less. The method was implemented on a 4 Tesla Varian research console and a clinical 3 Tesla Siemens Trio scanner. Human brain spectra acquired in vivo from the prefrontal cortex at TE = 8 ms showed improved signals from coupled resonances (such as glutamate, glutamine, and myo‐inositol) compared to spectra acquired at TE = 30 ms. These improvements should result in more accurate quantitation of these metabolites. Magn Reson Med 52:898–901, 2004. © 2004 Wiley‐Liss, Inc.