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Localized 7 Li MR spectroscopy and spin relaxation in rat brain in vivo
Author(s) -
Komoroski Richard A.,
Pearce John M.
Publication year - 2004
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20112
Subject(s) - nuclear magnetic resonance , in vivo , relaxation (psychology) , spin–lattice relaxation , spectroscopy , lithium (medication) , isotopes of lithium , chemistry , in vivo magnetic resonance spectroscopy , nuclear magnetic resonance spectroscopy , nuclear medicine , magnetic resonance imaging , physics , medicine , ion , biology , microbiology and biotechnology , radiology , quantum mechanics , nuclear quadrupole resonance , organic chemistry , ion exchange
Localized 7 Li MR point‐resolved spectroscopy (PRESS) was developed as a technique to measure lithium (Li) concentration in rat brain in vivo. Localized 7 Li spectra could be obtained at 4.7 T in a 0.7‐ml voxel in rat brain over the entire therapeutic range of serum Li for humans. Localized 7 Li spin‐lattice ( T 1 ) and spin–spin ( T 2 ) relaxation times were measured. Measured intensities were corrected for spin relaxation effects and 7 Li MR visibility in vivo. The average T 1 was 3.3 ± 0.9 sec, and the average T 2 was 82 ± 20 ms. Neither T 1 nor T 2 correlated with brain concentration. No statistically significant change was found in either T 1 or T 2 from ∼7–17 days of Li dosing. Magn Reson Med 52:164–168, 2004. © 2004 Wiley‐Liss, Inc.