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MRI measurement of liver regeneration in mice following partial hepatectomy
Author(s) -
Garbow J.R.,
Kataoka M.,
Flye M.W.
Publication year - 2004
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20107
Subject(s) - liver regeneration , hepatectomy , regeneration (biology) , in vivo , magnetic resonance imaging , medicine , liver tissue , resection , nuclear medicine , radiology , surgery , biology , microbiology and biotechnology
Improvements in noninvasive imaging modalities are crucial for preoperative in vivo assessments of liver condition and potential for regeneration after liver resection for removal of liver tumors. To that end, an MRI study of liver regeneration in mice following partial hepatectomy is described and validated. Hepatic volumes were accurately measured from contrast‐enhanced, gradient‐echo images of the liver. Regeneration curves were constructed for a series of mice ( N = 6) from a longitudinal MR study, with images collected 1, 2, 3, 4, 5, and 9 days following surgery. We validated the MR method by correlating serial MR‐measured volumes with liver wet weight. The success of this method will enable future studies to better elucidate the factors that affect regeneration, and help to optimize the timing and dosing of chemotherapeutics to minimize their deleterious effects on liver regeneration. Magn Reson Med 52:177–180, 2004. © 2004 Wiley‐Liss, Inc.