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Fast acquisition‐weighted three‐dimensional proton MR spectroscopic imaging of the human prostate
Author(s) -
Scheenen Tom W.J.,
Klomp Dennis W.J.,
Röll Stefan A.,
Fütterer Jurgen J.,
Barentsz Jelle O.,
Heerschap Arend
Publication year - 2004
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20103
Subject(s) - voxel , prostate , nuclear magnetic resonance , signal (programming language) , nuclear medicine , human breast , choline , proton , biomedical engineering , computer science , materials science , chemistry , physics , medicine , artificial intelligence , cancer , cancer cell , programming language , biochemistry , quantum mechanics
The clinical application of 3D proton spectroscopic imaging (3D SI) of the human prostate requires a robust suppression of periprostatic lipid signal contamination, minimal intervoxel signal contamination, and the shortest possible measurement time. In this work, a weighted elliptical sampling of k ‐space, combined with k ‐space filtering and pulse repetition time (TR) reduction minimized lipid signals, intervoxel contamination, and measurement time. At 1.5 T, the MR‐visible prostate metabolites citrate, creatine, and choline can now be mapped over the entire human prostate with uncontaminated spherical voxels, with a volume down to 0.37 cm 3 , in measurement times of 7–15 min. Magn Reson Med 52:80–88, 2004. © 2004 Wiley‐Liss, Inc.