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Optimized interleaved whole‐brain 3D double inversion recovery (DIR) sequence for imaging the neocortex
Author(s) -
Boulby P.A.,
Symms M.R.,
Barker G.J.
Publication year - 2004
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20088
Subject(s) - neocortex , partial volume , inversion (geology) , computer science , sequence (biology) , magnetic resonance imaging , nuclear magnetic resonance , neuroscience , nuclear medicine , medicine , psychology , radiology , chemistry , physics , biology , paleontology , structural basin , biochemistry
For a substantial number of individuals with neurological disorders, a conventional MRI scan does not reveal any obvious etiology; however, it is believed that abnormalities in the neocortical gray matter (GM) underlie many of these disorders. Attempts to image the neocortex are hindered by its thin, convoluted structure, and the partial volume (PV) effect. Therefore, we developed a 3D version of the double inversion recovery (DIR) sequence that incorporates an optimized interleaved (OIL) strategy to improve efficiency and allow high‐quality, high‐resolution imaging of GM. Magn Reson Med 51:1181–1186, 2004. © 2004 Wiley‐Liss, Inc.