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Human imaging of phosphorus in cortical and trabecular bone in vivo
Author(s) -
Robson Matthew D.,
Gatehouse Peter D.,
Bydder Graeme M.,
Neubauer Stefan
Publication year - 2004
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20055
Subject(s) - cortical bone , nuclear magnetic resonance , in vivo , pulse (music) , chemistry , nuclear medicine , pulse sequence , trabecular bone , materials science , biomedical engineering , optics , anatomy , medicine , pathology , physics , biology , osteoporosis , microbiology and biotechnology , detector
Phosphorus was imaged in vivo in human cortical and trabecular bone and the T 1 and T 2 *were measured. An ultrashort TE (UTE) pulse sequence (TE = 70 μm) was used with half pulse excitation and radial mapping of k ‐space from the center out. T 2 *was measured using multiple echo times and T 1 was measured both by saturation recovery and by a method using different RF pulse amplitudes. Seven normal subjects (32–85 years) were examined. Phosphorus was imaged, with a true in‐plane resolution of 2.9 × 2.9 mm and a signal‐to‐noise ratio (SNR) of 19:1, in both cortical and trabecular bone. The mean T 2 *value was 207 ± 12 μs, and the mean T 1 value was 8.6 ± 3.0 sec. Images and measurements were obtained in realistic times on a clinical MR system. This may provide a new approach to characterizing disease of bone. Magn Reson Med 51:888–892, 2004. © 2004 Wiley‐Liss, Inc.