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Assessment of myocardial infarction in pigs using a rapid clearance blood pool contrast medium
Author(s) -
Dewey Marc,
Kaufels Nicola,
Laule Michael,
Schnorr Jörg,
Wagner Susanne,
Kivelitz Dietmar,
Raynaud JeanSébastien,
Robert Philippe,
Hamm Bernd,
Taupitz Matthias
Publication year - 2004
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.20046
Subject(s) - myocardial infarction , infarction , medicine , nuclear medicine , contrast medium , contrast (vision) , limits of agreement , contrast enhancement , magnetic resonance imaging , radiology , physics , optics
Delayed enhancement MRI using extracellular contrast media allows reliable detection of myocardial infarction. If blood pool contrast media like P792 (Vistarem, Guerbet, France), in addition to improving coronary MR angiography, can be shown to also produce delayed enhancement in myocardial infarction they could improve the prerequisites for a comprehensive cardiac MR examination. In this study reperfused myocardial infarction in five minipigs was imaged with an inversion‐recovery fast low‐angle shot sequence using P792 (0.013 mmol Gd/kg) and the extracellular contrast medium Gd‐DOTA (Dotarem, 0.1 mmol Gd/kg, Guerbet). The infarction size determined on MRI using P792 (7.55 ± 2.31 cm 2 ) highly correlated both with histomorphometry (7.81 ± 2.18 cm 2 , r = 0.991, P < 0.002) and with MRI using Gd‐DOTA (7.85 ± 2.35 cm 2 , r = 0.978, P < 0.005). Bland‐Altman analysis showed that the limit of agreement of MRI using P792 compared to histomorphometry was 3.3 ± 7.6% of the infarction size. The contrast‐to‐noise ratio between infarcted and remote myocardium was not significantly different between Gd‐DOTA (5.9 ± 2.4) and P792 (4.4 ± 1.1, P = 0.5). The blood pool contrast medium P792 allows reliable assessment of viability with good contrast and accuracy. Magn Reson Med 51:703–709, 2004. © 2004 Wiley‐Liss, Inc.