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Capillary transfer constant of Gd‐DTPA in the myocardium at rest and during vasodilation assessed by MRI
Author(s) -
FritzHansen Thomas,
Rostrup Egill,
Sørndergaard Lars,
Ring Pod B.,
Amtorp Ole,
Larsson Henrik B. W.
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910400619
Subject(s) - vasodilation , perfusion , medicine , ischemia , cardiology , dipyridamole , nuclear medicine
The purpose of this study was to determine whether the capillary transfer constant ( K i ) of gadolinium‐DTPA was sensitive to perfusion changes and whether ischemic regions in the myocardium could be identified using the modified Kety formula. K i was measured at rest and during dipyridamole‐induced vasodilation in 10 healthy volunteers and in 10 patients with ischemic heart disease. K i increased by a factor of 2.5 ± 1.2 (mean ± SD) from 55 ± 16 ml 100 g −1 min −1 at rest to 136 ± 46 ml 100 9 −1 min −1 ( P < 0.01) during vasodilation in the healthy subjects. In the patients, there were no changes in K i during vasodilation in ischemic regions (50 ± 18 versus 49 ± 30 ml 100 g −1 min −1 (P > 04)). K i increased in nonischemic regions by a factor of 2.0 ± 0.8 from 44 ± 17 to 81 ± 32 ml 100 g −1 min −1 during vasodilation ( P < 0.02). It is concluded that the capillary transfer constant is sensitive to perfusion changes and that regional ischemia can be detected with MRI. This noninvasive and quantitative method may prove useful in the evaluation of patients with ischemic heart disease.