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Simultaneous oxygenation and perfbsion imaging study of functional activity in primary visual cortex at different visual stimulation frequency: Quantitative correlation between BOLD and CBF changes
Author(s) -
Zhu XiaoHong,
Kim SeongGi,
Andersen Peter,
Ogawa Seiji,
Uğgurbil Kamil,
Chen Wei
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910400510
Subject(s) - visual cortex , correlation , cerebral blood flow , neuroscience , stimulation , linear correlation , brain activity and meditation , blood oxygenation , cortex (anatomy) , oxygenation , psychology , functional magnetic resonance imaging , medicine , electroencephalography , mathematics , statistics , geometry
A relationship between regional cerebral blood flow (CBF) and blood oxygenation level dependent (BOLD) changes in the primary visual cortex (V1) at varied visual stimulation fre quency has been examined quantitatively using the multislice FAIR technique. A linear correlation in the common activation areas between functional BOLD and CBF maps was observed. This supports the hypothesis that the task‐stimulated BOLD changes in microvasculature are correlated with the CBF changes that presumably reflect the degree of neuronal ac tivity. The linear correlation coefficients for intrasubject com parisons are more significant than those for intersubject com parisons. This suggests that using intrasubject comparisons for quantitative studies of neuronal activity related to different task stimuli and task performances should be more reliable than using intersubject comparisons.