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Strategy for lipid suppression in lactate imaging using STIR‐DQCT: A study of hypoxic‐ischemic brain injury
Author(s) -
Nakai Toshiharu,
Rhine William D.,
Okada Tomohisa,
Stevenson David K.,
Spielman Daniel M.
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910400416
Subject(s) - in vivo , hypoxia (environmental) , chemistry , imaging phantom , medicine , nuclear medicine , oxygen , biology , microbiology and biotechnology , organic chemistry
In vivo lactate detection using gradient enhanced double quantum coherence transfer (DQCT) was significantly improved by addition of short‐time‐inversion‐recovery (STIR). Phantom studies demonstrated lipid suppression down to the background noise level with 33% loss of lactate signal. In vivo studies using a rabbit model of hypoxic and unilateral‐ischemic brain injury showed reduction down to 29 ± 11% in lipids with inversion times between 140 and 170 ms. Lactate signals on the ischemic side were 51 ± 53% higher than the nonischemic side at the peak of hypoxia. STIR‐DQCT can be a useful robust method of obtaining metabolic maps of lactate in vivo .