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Quantitative spectroscopic imaging of the human brain
Author(s) -
Pan Jullie W.,
Twieg Donald B.,
Hetherington Hoby P.
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910400305
Subject(s) - creatine , nuclear magnetic resonance , cerebrospinal fluid , choline , nuclear medicine , human brain , magnetic resonance imaging , chemistry , medicine , pathology , physics , radiology , biochemistry , psychiatry
A method to provide B 1 correction and cerebrospinal fluid (CSF) referencing is developed and applied to spectroscopic imaging of the human brain at 4.1 T using a volume head coil. The B 1 image allows rapid determination of the spatially dependent B 1 that is then used to compensate for the B 1 sensitivity of the spectroscopic sequence. The reference signal is acquired from CSF located in a lateral ventricular position using a point‐resolved echo spectroscopy (PRESS) acquisition. The CSF spectrum is also corrected for B 1 dependence. Together with T 2 and T 1 corrections, this method is used to provide quantitative values of N ‐acetylaspartate (NAA), creatine (Cr), and choline (Ch). The metabolite concentrations obtained from a spectroscopic imaging slice through the ventricles in seven normal controls are in good agreement with previously published literature values. This method is applied in a patient with secondary progressive multiple sclerosis, showing separate areas of abnormalities in both NAA and Cr.