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Hyperpolarized 3 He NMR Lineshape Measurements in the Live Guinea Pig Lung
Author(s) -
Chen X. Josette,
Chawla Mark S.,
Cofer Gary P.,
Hedlund Laurence W.,
Moller Harald E.,
Johnson G. Allan
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910400109
Subject(s) - nuclear magnetic resonance , chemistry , radiochemistry , physics
Spatially localized lineshapes of hyperpolarized (HP) 3 He in guinea pig lungs have been measured in vivo . Three different axial slice locations, each containing different compositions of airway sizes and orientations, were studied. Gas peaks from major bronchi (2 ppm) and alveoli (‐2 ppm) were distinguished. The gas phase spectra show structural features that are a result of frequency shifts caused by bulk magnetic susceptibility. For a given slice, the spectral lineshapes reflect the airway composition within the slice location, according to theory. The peak assignments given here also agree with previous studies done by Wagshul et at . with HP 129 Xe. At each of the slice locations, data were acquired during two phases of the breathing cycle, resulting in a relative frequency shift of ∼0.3 ppm in the superior slices. Spectra obtained over a number of breaths show the dynamics of the gas buildup in the lung and provide further evidence supporting the peak assignments.