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Magnetic resonance microimaging for noninvasive quantification of myocardial function and mass in the mouse
Author(s) -
Ruff Jan,
Wiesmann Frank,
Hiller KarlHeinz,
Voll Sabine,
von Kienlin Markus,
Bauer Wolfgang R.,
Rommel Eberhard,
Neubauer Stefan,
Haase Axel
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910400106
Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , function (biology) , materials science , chemistry , physics , medicine , radiology , biology , evolutionary biology
The purpose of this work was to develop high‐resolution cardiac magnetic resonance imaging techniques for the in vivo mouse model for quantification of myocardial function and mass. Eight male mice were investigated on a 7‐Tesla MRI scanner. High‐quality images in multiple short axis slices (in‐plane resolution 117 μm 2 , slice thickness 1 mm) were acquired with an ECG‐gated cine sequence. Left ventricular end‐diastolic and end‐systolic volumes and mass were calculated from segmented slice volumes. There was precise agreement of left ventricular mass determined ex vivo and by MRI. lntraobserver (5%) and interobserver (5%) variability of in vivo MR measurements were low.