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Fast imaging of phosphocreatine using a RARE pulse sequence
Author(s) -
Greenman Robert L.,
Elliott Mark A.,
Vandenborne Krista,
Schnall Mitchell D.,
Lenkinski Robert E.
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390523
Subject(s) - phosphocreatine , nuclear magnetic resonance , pulse sequence , pulse (music) , signal (programming language) , sequence (biology) , chemistry , physics , optics , medicine , computer science , biochemistry , detector , programming language , energy metabolism
A technique is described for acquiring phosphocreatine (PCr) images of skeletal muscle using a rapid acquisition with relaxation enhancement (RARE) pulse sequence. All of the phosphorus metabolites other than PCr are forced to dephase within the first few echoes, whereas the Carr‐Purcell Mei‐boom‐Gill (CPMG) pulse sequence maintains a high PCr signal long enough to acquire 64 echoes in a single shot. Axial PCr images of a human forearm with a signal‐to‐noise ratio of 9 were acquired in 2 min. The effect of the refocusing pulse section profile on the ratio of desired to undesired metabolite signal is demonstrated.