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Multislice imaging of quantitative cerebral perfusion with pulsed arterial spin labeling
Author(s) -
Yang Yihong,
Frank Joseph A.,
Hou Lei,
Ye Frank Q.,
McLaughlin Alan C.,
Duyn Jeff H.
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390520
Subject(s) - multislice , arterial spin labeling , cerebral blood flow , nuclear magnetic resonance , spins , perfusion , positron emission tomography , perfusion scanning , nuclear medicine , biomedical engineering , chemistry , physics , medicine , radiology , cardiology
A method is presented for multislice measurements of quantitative cerebral perfusion based on magnetic labeling of arterial spins. The method combines a pulsed arterial inversion, known as the FAIR (Flow‐sensitive Alternating Inversion Recovery) experiment, with a fast spiral scan image acquisition. The short duration (22 ms) of the spiral data collection allows simultaneous measurement of up to 10 slices per labeling period, thus dramatically increasing efficiency compared to current single slice acquisition protocols. Investigation of labeling efficiency, suppression of unwanted signals from stationary as well as intraarterial spins, and the FAIR signal change as a function of inversion delay are presented. The assessment of quantitative cerebral blood flow (CBF) with the new technique is demonstrated and shown to require measurement of arterial transit time as well as suppression of intraarterial spin signals. CBF values measured on normal volunteers are consistent with results obtained from H 2 O 15 positron emission tomography (PET) studies and other radioactive tracer approaches. In addition, the new method allows detection of activation‐related perfusion changes in a finger‐tapping experiment, with locations of activation corresponding well to those observed with blood oxygen level dependent (BOLD) fMRI.