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Quantitative assessment of bone marrow hematopoiesis using parametric magnetic resonance imaging
Author(s) -
Ballon Douglas,
Jakubowski Ann A.,
Tulipano Paola K.,
Graham Martin C.,
Schneider Erika,
Aghazadeh Behzad,
Chen QinSheng,
Koutcher Jason A.
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390517
Subject(s) - magnetic resonance imaging , bone marrow , nuclear magnetic resonance , haematopoiesis , parametric statistics , bone marrow diseases , medicine , nuclear medicine , pathology , radiology , physics , biology , stem cell , mathematics , statistics , genetics
Spatial maps of the percentage cellularity in pelvic bone marrow were calculated at a resolution of 15.6 mm 3 from six volunteers and 10 patients treated for documented hematologic disease using a three‐point Dixon MRI pulse sequence. The percentage cellularity calculation was aided by analyzing a two‐dimensional feature space consisting of the apparent water fraction ( W a ), and the T 2 relaxation time of water ( T 2w ). An extracellular water fraction was assigned to each voxel on the basis of a two‐component T 2w algorithm. In six cases, the method was compared to results obtained from core biopsies or aspirates of the posterior iliac crest. The results indicate that segmentation schemes that combine high‐quality phase‐contrast imaging with nuclear relaxation time measurements can potentially identify the true fractional marrow volume occupied by hematopoietic elements in a variety of clinical situations.