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Influence of aging or left ventricular hypertrophy on the human heart: Contents of phosphorus metabolites measured by 31 P MRS
Author(s) -
Okada Mamoru,
Mitsunami Kenichi,
Inubushi Toshiro,
Kinoshita Masahiko
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390515
Subject(s) - left ventricular hypertrophy , cardiac hypertrophy , muscle hypertrophy , phosphorus , medicine , cardiology , human heart , chemistry , blood pressure , organic chemistry
Although both aging and hypertrophy are extremely important factors for cardiac performance, their influence on cardiac metabolism, especially that of high‐energy phosphates, has not been fully elucidated as yet. Quantitative measurements of high‐energy phosphates were attempted by comparing myocardial 31 P NMR spectra with an external reference using depth‐resolved surface‐coil spectroscopy. The voxel size of the region of interest (ROI) was disk‐shaped with 15‐cm diameter and 25‐mm thickness, but the left ventricular weight actually involved in the ROI was estimated to be between 22 and 66 g using MRI. Myocardial phosphocreatine (PCr) content and adenosine triphosphate (ATP) content for the 30 normal volunteers showed significant age dependence since both decreased in relation to increasing age. Myocardial PCr content and ATP content in patients with hypertension did not differ significantly from the age‐matched control group. PCr content (6.1 ± 2.2 μmol/g wet tissue, n =10) and ATP content (4.1 ±1.3 μmol/g wet tissue) in patients with hypertrophic cardiomyopathy were less than the age‐matched control group ( n = 15; PCr: 9.7 ± 2.5 μmol/g wet tissue, P <0.01; ATP: 6.4 ±1.8 μmol/g wet tissue, P <0.05), respectively. These results indicate that quantitative 31 P MRS may be valuable in the assessment of changes in high‐energy phosphate metabolism caused by aging or hypertrophy.