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Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II)
Author(s) -
Wong Eric C.,
Buxton Richard B.,
Frank Lawrence R.
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390506
Subject(s) - subtraction , perfusion , transit time , mean transit time , arterial spin labeling , perfusion scanning , nuclear medicine , computer science , image subtraction , artificial intelligence , medicine , mathematics , radiology , image processing , binary image , arithmetic , transport engineering , engineering , image (mathematics)
In the pulsed arterial spin labeling (ASL) techniques EPISTAR, PICORE, and FAIR, subtraction of two images in which inflowing blood is first tagged and then not tagged yields a qualitative map of perfusion. An important reason this map is not quantitative is that there is a spatially varying delay in the transit of blood from the tagging region to the imaging slice that cannot be measured from a single subtraction. We introduce here two modifications of pulsed ASL (QUIPSS and QUIPSS II) that avoid this problem by applying additional saturation pulses to control the time duration of the tagged bolus, rendering the technique relatively insensitive to transit delays and improving the quantitation of perfusion.