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Blood oxygen saturation assessment in vivo using T 2 * estimation
Author(s) -
Li Debiao,
Wang Yi,
Waight David J.
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390503
Subject(s) - blood flow , oxygen saturation , venous blood , saturation (graph theory) , pulsatile flow , oxygen , hemoglobin , arterial blood , hemodynamics , in vivo , biomedical engineering , medicine , anesthesia , chemistry , cardiology , mathematics , biology , microbiology and biotechnology , organic chemistry , combinatorics
The feasibility of noninvasively assessing hemoglobin oxygen saturation of deep blood vessels in vivo by measuring blood T 2 * is investigated. Techniques for blood T 2 * measurements in major arteries and veins in the presence of pulsatile blood flow are presented and validated using a flow phantom. Images of multiple TEs were collected in a paired fashion. Cardiac triggering was used to eliminate image artifacts caused by pulsatile arterial blood flow. Using these techniques, it was found that the T 2 * of arterial blood (199 ± 8 ms) is significantly greater than that of venous blood (108 ± 6 ms) in 10 volunteers, consistent with the fact that the oxygen saturation level of arterial blood is much larger than that of venous blood. Various oxygen saturation levels were created in vivo in a pig and the blood T 2 * was shown to increase with oxygen saturation levels over a wide range. Preliminary results of this study indicate that it is feasible to assess local oxygen saturation by measuring blood T 2 * using the proposed techniques.