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Proton T 2 relaxation of cerebral metabolites during transient global ischemia in rat brain
Author(s) -
Fujimori Hiroyuki,
Michaelis Thomas,
Wick Markus,
Frahm Jens
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390419
Subject(s) - metabolite , ischemia , nuclear magnetic resonance , relaxation (psychology) , proton , in vivo , brain ischemia , chemistry , medicine , physics , biology , microbiology and biotechnology , quantum mechanics
Putative changes of metabolite T 2 relaxation times were investigated before and after a 20‐min period of global ischemia in rat brain in vivo (n= 10) using localized proton MRS at different echo times (2.35 T). Neither absolute T 2 relaxation times (TE = 20‐270 ms) nor time courses of T 2 ‐weighted metabolite signals (TE = 135 ms) revealed statistically significant changes during the occlusion or early reperfusion relative to pre‐ischemic baseline. These findings are in line with reports of relaxation changes at much later stages and further demonstrate that altered T 2 relaxation is not a confounding factor in diffusion‐weighted long‐TE proton MRS during early ischemic events.