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Identification of a high concentration of scyllo ‐inositol in the brain of a healthy human subject using 1 H‐ and 13 C‐NMR
Author(s) -
Seaquist Elizabeth R.,
Gruetter Rolf
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390220
Subject(s) - inositol , chemistry , nuclear magnetic resonance , biochemistry , receptor , physics
Abstract The peak at 3.35 ppm in the 1 H‐NMR spectrum characteristic for scyllo ‐inositol may be a marker for cerebral pathology, although it has a well‐known constant concentration relative to myo ‐inositol. Such a peak was observed with an intensity at least 300% above normal in the brain of a healthy volunteer. The scyllo ‐inositol signal was assigned based on the detection of a corresponding peak at 74.5 ppm in the 13 C‐NMR spectrum and on the demonstration of singlet characteristics of the proton signal. The presence of substantial brain concentrations of scyllo ‐inositol suggests that scyllo ‐inositol metabolism may be regulated independently from myo ‐inositol and that such concentrations are compatible with normal health.