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Localized proton NMR spectroscopy in the striatum of patients with idiopathic spasmodic torticollis
Author(s) -
Möller Harald E.,
VollmerHaase Juliane,
Wiedermann Dirk,
Schuierer Gerhard
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390219
Subject(s) - spasmodic torticollis , basal ganglia , striatum , torticollis , chemistry , metabolite , nuclear medicine , choline , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , medicine , endocrinology , central nervous system , surgery , dopamine , stereochemistry , physics
Single voxel proton spectroscopy was used to study brain metabolism in idiopathic spasmodic torticollis. Peak metabolite ratios in long echo time (135 ms) spectra were evaluated in the basal ganglia of 16 patients (29‐65 years). Eight of them were untreated; the other eight were examined 4‐6 weeks after administration of botulinum toxin type A. As compared with 60 control spectra, patients showed a significant, therapy‐resistant decrease in N ‐acetyl‐L‐aspartate (NAA)/choline (Cho). NAA/cre‐atine (Cr) and Cho/Cr were close to normal in the post‐treatment group but significantly reduced in untreated patients. This result is consistent with the hypothesis that striatal Cr is reversibly elevated in chronic muscle stimulation. The right and left stria‐tum were affected to the same extent.