Premium
In vivo measurement of changes in venous blood‐oxygenation with high resolution functional MRI at 0.95 Tesla by measuring changes in susceptibility and velocity
Author(s) -
Hoogenraad Frank G. C.,
Reichenbach Jürgen R.,
Haacke E. Mark,
Lai Song,
Kuppusamy Karthikeyan,
Sprenger Michiel
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390116
Subject(s) - oxygenation , nuclear magnetic resonance , blood oxygenation , blood volume , blood flow , venous blood , oxygen , chemistry , high resolution , in vivo , signal (programming language) , oxygen saturation , magnetic resonance imaging , biomedical engineering , nuclear medicine , cardiology , medicine , radiology , functional magnetic resonance imaging , physics , biology , remote sensing , microbiology and biotechnology , organic chemistry , geology , computer science , programming language
High‐resolution functional imaging experiments at 0.95 Tesla have been performed to determine the changes in oxygen saturation in pial veins during motor activation by measuring both flow and susceptibility changes in the blood. Averaging across subjects, mean values for the change of the oxygenation level, δY = 0.16 ± 0.08 (n = 7) and δY = 0.13 ± 0.09 (n = 4), were obtained from the susceptibility sensitive and the flow sensitive acquisitions, respectively. The results suggest that the increase in blood flow is largely uncoupled from the oxygen consumption. The quoted errors reflect mainly the inter‐subject variability. In addition, low‐resolution echo planar imaging (EPI) measurements were performed on the same volunteers to quantify signal intensity changes. Using the measured change in oxygenation, the observed signal changes in the EPI experiments can be attributed to a 5% venous blood volume.