Premium
Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1 H magnetic resonance spectroscopy
Author(s) -
Wang Yonker,
Li ShiJiang
Publication year - 1998
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910390107
Subject(s) - white matter , creatine , phosphocreatine , metabolite , chemistry , nuclear magnetic resonance , choline , human brain , cerebrospinal fluid , magnetic resonance imaging , biology , pathology , biochemistry , physics , medicine , endocrinology , neuroscience , radiology , energy metabolism
Abstract Differentiation of absolute metabolite concentrations between gray and white matter in the occipital region of normal human brain was performed by in vivo localized single‐voxel 1 H magnetic resonance spectroscopy at 1.5 Testa with long echo time (136 ms). With the combination of image segmentation between white and gray matter and cerebrospinal fluid, signal compensation of T, and T 2 effects, tissue water signal as the internal concentration reference, as well as compensation by different water contents in gray and white matters, it was determined that the levels of N‐acetylaspartate (NAA), creatine and/or phosphocreatine (Cr), and choline‐containing compounds (Cho) in gray matter were significantly higher than in white matter. The averaged NAA, Cr, and Cho concentrations in gray matter were 11.0, 9.7, and 1.9 mM/liter, respectively, in comparison with 7.5, 5.2, and 1.6 mM/liter in white matter. These results suggest that precise composition of white and gray matter and cerebrospinal fluid is necessary to avoid partial voluming effect in a single voxel and to accurately quantify the metabolite concentrations.