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MRI quantitative myocardial perfusion with compartmental analysis: A rest and stress study
Author(s) -
Vallée JeanPaul,
Sostman H. Dirk,
Macfall James R.,
Wheeler Ted,
Hedlund Larry W.,
Spritzer Charles E.,
Coleman R. Edward
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380618
Subject(s) - dipyridamole , perfusion , blood flow , nuclear medicine , bolus (digestion) , in vivo , perfusion scanning , chemistry , nuclear magnetic resonance , medicine , physics , microbiology and biotechnology , biology
K 1 (first‐order transfer constant from arterial plasma to myocardium for Gd‐DTPA) and Vd (distribution volume of Gd‐DTPA in myocardium) were measured in vivo in a canine model ( n = 5) using MRI‐derived myocardial perfusion curves and a compartmental model. Perfusion curves were obtained after a bolus injection of Gd‐DTPA (0.04 m M /kg) with an inversion‐prepared fast gradient echo sequence. Myocardium and blood signal intensity were converted to a concentration of Gd‐DTPA, according to a model appropriate for short (<1 s) interimage intervals characteristic of cardiac‐triggered acquisitions. Before dipyridamole‐induced stress, K 1 and Vd , obtained from the fit of the MRI‐derived perfusion curves, were 6.2 ± 1.4 (mHz) and 17.5 ± 4.2%, respectively. After dipyridamole infusion, a K 1 increase of a factor of 2.82 ± 0.72 was measured ( P = 0.003). No change was observed in Vd ( P = 0.98). These results suggest that the K 1 increase after dipyridamole reflects a flow‐related effect that can be useful to quantity the MRI‐derived perfusion curves.