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Functional MRI bold signal coincides with electrical activity in the rat whisker barrels
Author(s) -
Yang Xiaojin,
Hyder Fahmeed,
Shulman Robert G.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380604
Subject(s) - functional magnetic resonance imaging , premovement neuronal activity , stimulation , whisker , perfusion , signal (programming language) , neuroscience , functional imaging , blood oxygenation , nuclear magnetic resonance , blood oxygen level dependent , somatosensory system , brain mapping , magnetic resonance imaging , biomedical engineering , chemistry , physics , computer science , medicine , psychology , cardiology , radiology , programming language
Functional MRI (fMRI) provides a noninvasive method for mapping brain functional activity based on blood oxygenation level dependent (BOLD) image contrast that is primarily due to localized increases in perfusion. Recently, Malonek and Grinvald ( Science 272:551–554, 1996) suggested that during sustained functional activation, the increases in perfusion were spread over a much larger area than the localized electrical activity. In this study, it is demonstrated that the spatial distribution of the BOLD fMRI signal during sustained stimulation of rat whiskers has the same spatial pattern and dimension as that of neuronal electrical activity in the rat whisker barrels.