T  1ρ ‐relaxation in articular cartilage: Effects of enzymatic degradation | Zendy

Duvvuri Umamaheswar | Zendy; Reddy Ravinder | Zendy; Patel Saurabh D. | Zendy; Kaufman Jonathan H. | Zendy; Kneeland J. Bruce | Zendy; Leigh John S. | Zendy

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T 1ρ ‐relaxation in articular cartilage: Effects of enzymatic degradation

Author(s) -

Duvvuri Umamaheswar,

Reddy Ravinder,

Patel Saurabh D.,

Kaufman Jonathan H.,

Kneeland J. Bruce,

Leigh John S.

Publication year - 1997

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910380602

Subject(s) - proteoglycan , articular cartilage , osteoarthritis , chemistry , cartilage , nuclear magnetic resonance , magnetization transfer , dispersion (optics) , relaxation (psychology) , biomedical engineering , anatomy , magnetic resonance imaging , pathology , medicine , optics , physics , radiology , alternative medicine

Spin‐lattice relaxation in the rotating frame ( T 1ρ ) dispersion spectroscopy and imaging were used to study normal and enzymatically degraded bovine articular cartilage. Normal specimens demonstrate significant T 1ρ “dispersion” (∼60 to ∼130 ms) in the 100 Hz to 9 kHz frequency range. Proteoglycan‐degraded specimens have 33% greater T 1ρ values than collagen‐degraded or normal samples. T 1ρ ‐weighted images reveal structure not found in conventional T 1 ‐or T 2 ‐weighted images. Our results suggest that T 1ρ measurements are selectively sensitive to proteoglycan content. The potential of this method in distinguishing the early degenerative changes in cartilage associated with osteoarthritis is discussed.

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