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T 1ρ ‐relaxation in articular cartilage: Effects of enzymatic degradation
Author(s) -
Duvvuri Umamaheswar,
Reddy Ravinder,
Patel Saurabh D.,
Kaufman Jonathan H.,
Kneeland J. Bruce,
Leigh John S.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380602
Subject(s) - proteoglycan , articular cartilage , osteoarthritis , chemistry , cartilage , nuclear magnetic resonance , magnetization transfer , dispersion (optics) , relaxation (psychology) , biomedical engineering , anatomy , magnetic resonance imaging , pathology , medicine , optics , physics , radiology , alternative medicine
Spin‐lattice relaxation in the rotating frame ( T 1ρ ) dispersion spectroscopy and imaging were used to study normal and enzymatically degraded bovine articular cartilage. Normal specimens demonstrate significant T 1ρ “dispersion” (∼60 to ∼130 ms) in the 100 Hz to 9 kHz frequency range. Proteoglycan‐degraded specimens have 33% greater T 1ρ values than collagen‐degraded or normal samples. T 1ρ ‐weighted images reveal structure not found in conventional T 1 ‐or T 2 ‐weighted images. Our results suggest that T 1ρ measurements are selectively sensitive to proteoglycan content. The potential of this method in distinguishing the early degenerative changes in cartilage associated with osteoarthritis is discussed.