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A simplified sequence for observing deoxymyoglobin signals in vivo : Myoglobin excitation with dynamic unexcitation and saturation of water and fat (MEDUSA)
Author(s) -
Noyszewski Elizabeth A.,
Chen EnnLing,
Reddy Ravinder,
Wang Zhiyue,
Leigh John S.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380515
Subject(s) - myoglobin , in vivo , excitation , nuclear magnetic resonance , pulse sequence , chemistry , pulse (music) , biophysics , sequence (biology) , physics , biology , optics , biochemistry , microbiology and biotechnology , quantum mechanics , detector
Abstract This paper describes a new, simplified pulse sequence for observing NMR signals from deoxymyoglobin in vivo. Paramagnetically shifted resonances from deoxymyoglobin can be exploited to noninvasively calculate intracellular oxygen tension in striated muscle. However, special sequences are required to observe these weak signals against the larger water and fat signals encountered in vivo. The pulse sequence described here, which is based on inversion recovery sequences, efficiently suppresses both water and fat resonances and can be implemented with short repetition rates. Moreover, it is perfectly suited for studies with surface coils, where RF inhomogeneities render other popular suppression sequences ineffective.