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Magnetic resonance properties of ex vivo breast tissue at 1.5 T
Author(s) -
Graham Simon J.,
Ness Sola,
Hamilton Bradford S.,
Bronskill Michael J.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380422
Subject(s) - nuclear magnetic resonance , magnetization transfer , relaxation (psychology) , magnetization , adipose tissue , magnetic resonance imaging , in vivo , chemistry , materials science , medicine , physics , magnetic field , biology , radiology , biochemistry , microbiology and biotechnology , quantum mechanics
The magnetic resonance absorption spectrum, T 1 and T 2 relaxation time distributions, and magnetization transfer properties of ex vivo breast tissue have been characterized at 1.5 T and 37°C. The fraction of fibroglandular tissue within individual tissue samples ( n = 31) was inferred from the tissue volumetric water content obtained by integration of resolvable broad‐line fat and water resonances. The spectroscopically estimated water content was strongly correlated with that extracted enzymatically (Pearson correlation coefficient 0.98, P « 0.01), which enabled the assignment of principal relaxation components for fibroglandular tissue ( T 2 = 0.04 ± 0.01, T 1 = 1.33 ± 0.24 s), and for adipose tissue ( T 2 = 0.13 ± 0.01, T 1 = 0.23 ± 0.01 s, and T 2 = 0.38 ± 0.03, T 1 = 0.62 ± 0.16 s). The relaxation components for fibroglandular tissue exhibited strong magnetization transfer, whereas those for adipose tissue showed little magnetization transfer effect. These results ultimately have applicability to the optimization of clinical magnetic resonance imaging and research investigations of the breast.