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Effects of diffusion anisotropy on lesion delineation in a rat model of cerebral ischemia
Author(s) -
Lythgoe Mark F.,
Busza Albert L.,
Calamante Fernando,
Sotak Christopher H.,
King Martin D.,
Bingham Anna C.,
Williams Stephen R.,
Gadian David G.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380421
Subject(s) - diffusion mri , white matter , fractional anisotropy , anisotropy , effective diffusion coefficient , lesion , nuclear magnetic resonance , ischemia , nuclear medicine , medicine , magnetic resonance imaging , physics , radiology , pathology , optics , cardiology
The effects of white and gray matter diffusion anisotropy on ischemic lesion delineation have been studied in the rat model of middle cerebral artery occlusion. Apparent diffusion coefficient (ADC) maps obtained by conventional pulsed gradient spin echo diffusion‐weighted imaging (PGSE‐DWI) were compared with maps of the trace of the diffusion tensor in both normal and occluded animals. Diffusion tensor trace maps were derived from the average of the ADC maps from three separate experiments with diffusion weighting along three orthogonal axes, and also from a single‐scan method. A marked degree of diffusion anisotropy was observed in both cortical gray matter and white matter from ADC maps of the control animals. In the occluded animals, the systematic effects of anisotropy on ADC and lesion area influenced the delineation of the ischemic territory in the PGSE‐DWI ADC maps. However, the two trace methods eliminated these effects and gave consistent ischemic lesion depiction, despite the use of differing diffusion times in the two measurements.