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Increase of creatine kinase activity in the visual cortex of human brain during visual stimulation: A 31 p NMR magnetization transfer study
Author(s) -
Chen Wei,
Zhu XiaoHong,
Adriany Gregor,
Uǧurbil Kǎmil
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380408
Subject(s) - magnetization transfer , stimulation , visual cortex , nuclear magnetic resonance , creatine kinase , cortex (anatomy) , brain activity and meditation , neuroscience , chemistry , medicine , magnetic resonance imaging , psychology , electroencephalography , physics , radiology
31 P magnetic resonance spectroscopy was used to investigate changes in high energy phosphate levels and creatine kinase (CK) kinetics induced in the human visual cortex during photic stimulation. CK kinetics was evaluated by measuring the apparent unidirectional rate constant ( k f ) in the “forward” direction (i.e., in the direction of ATP synthesis from phosphocreatine). k f increased 34% in the visual cortex areas during stimulation without significant changes of steady‐state concentration of high energy phosphate compounds, indicating that CK turnover is elevated during increased neuronal activity.