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Regional measurement of the Gd‐DTPA tissue partition coefficient in canine myocardium
Author(s) -
Harris Paul A.,
Lorenz Christine H.,
Holburn George E.,
Overholser Knowles A.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380406
Subject(s) - hematocrit , perfusion , nuclear medicine , nuclear magnetic resonance , tracer , lambda , contrast (vision) , position (finance) , chemistry , physics , cardiology , medicine , nuclear physics , optics , finance , economics
Quantifiable MRI perfusion studies using the contrast agent Gd‐DTPA require measurement or estimation of the tissue partition coefficient (λ) for tracer kinetic modeling. Radiotracer techniques were used to obtain regional λ measurements from the left ventricles of five dogs. Measurements were analyzed to determine whether spatial heterogeneity was a major component of λ variability. No systematic variations were identified in terms of radial position, short‐axis slice location, or wall position. The high λ variability seen in this study and in cited data of others may be due in part to tissue heterogeneity in interstitial volume, plasma volume, and perfusate hematocrit.