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Diffusion‐weighted imaging of the human optic nerve: A New approach to evaluate optic neuritis in multiple sclerosis
Author(s) -
Iwasawa Tae,
Matoba Hiroko,
Ogi Akiko,
Kurihara Hiroaki,
Saito Kimihiko,
Yoshida Tetsuo,
Matsubara Sho,
Nozaki Atsushi
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380317
Subject(s) - optic neuritis , multiple sclerosis , medicine , optic nerve , magnetic resonance imaging , effective diffusion coefficient , ophthalmology , neuritis , intravoxel incoherent motion , diffusion mri , nuclear medicine , radiology , surgery , psychiatry
The apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion‐weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuritis and nine nerves with chronic neuritis. The mean ADC (4.18 ± 1.13 × 10 −3 mm 2 /s, n = 9) in the optic nerves with chronic neuritis was significantly higher than that in normal volunteers (1.56 ± 0.675 × 10 −3 mm 2 /s, n = 14) and that in the nerves with acute neuritis (0.94 ± 0.43 × 10 −3 mm 2 /s n = 4) (P < 0.001). The ADC is useful in assessing MS foci in the optic nerves.