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The effect of magnetization transfer on functional MRI signals
Author(s) -
Zhang Rongyan,
Cox Robert W.,
Hyde James S.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380205
Subject(s) - magnetization transfer , nuclear magnetic resonance , finger tapping , functional magnetic resonance imaging , signal (programming language) , magnetization , pulse sequence , pulse (music) , functional imaging , computer science , physics , magnetic resonance imaging , neuroscience , psychology , medicine , radiology , magnetic field , optics , quantum mechanics , detector , audiology , programming language
A magnetization transfer (MT)‐prepared echo‐planar imaging (EPI) pulse sequence was developed to study motor cortex activation, using a finger tapping paradigm. MT weighting resulted in a reduction of both the activated area and, in the majority of activated pixels, the functional MRI signal, regardless of the correlation coefficient threshold used in generating the activation map. The magnetization transfer ratio (MTR) was higher during task activation than during rest. Because the MT effect is strongly tissue‐dependent, these results support the hypothesis that incorporation of MT into functional MRI will help to understand the origin of the functional MRI signal.