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Stability constants and 1 H relaxation effects of ternary complexes formed between gd‐dtpa, gd‐dtpa‐bma, gd‐dota, and gd‐edta and citrate, phosphate, and carbonate ions
Author(s) -
Burai László,
Hietapelto Vesa,
Király RóBert,
Tóth éva,
Brücher Ernő
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910380120
Subject(s) - ternary operation , chemistry , ternary complex , phosphate , proton , dota , gadolinium , chelation , carbonate , ligand (biochemistry) , ion , relaxation (psychology) , stability constants of complexes , inorganic chemistry , nuclear chemistry , receptor , organic chemistry , social psychology , psychology , biochemistry , enzyme , physics , quantum mechanics , computer science , programming language
Abstract Formation of ternary complexes between Gd‐DTPA, Gd‐DTPA‐BMA, and Gd‐DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH <8. The complex Gd‐EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd‐EDTA( X ) ( X = CO 3 2‐ , Cit 3‐ ) results in a significant decrease in the proton relaxation rates under physiological conditions.