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Functional magnetic resonance imaging of median nerve stimulation in rats at 2.0 T
Author(s) -
Scanley B. Ellen,
Kennan Richard P.,
Cannan Susan,
Skudlarski Pawel,
Innis Robert B.,
Gore John C.
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370625
Subject(s) - functional magnetic resonance imaging , propofol , stimulation , magnetic resonance imaging , anesthetic , median nerve , medicine , anesthesia , neuroscience , nuclear magnetic resonance , nuclear medicine , psychology , anatomy , radiology , physics
Abstract An animal model of sensory activation using fMRI at 2.0 T has been developed, demonstrating that fMRI studies on animals need not be limited to high field magnets. These methods produced reliable image intensity changes of 2% using median nerve stimulation in rats at 3 Hz and propofol as the anesthetic agent. At 6 Hz the activation was slightly but not statistically significantly greater. The feasibility of fMRI studies in animals using propofol suggests that it may be a useful anesthetic for fMRI studies in agitated adult patients or in children.