Functional magnetic resonance imaging of median nerve stimulation in rats at 2.0 T | Zendy

Scanley B. Ellen | Zendy; Kennan Richard P. | Zendy; Cannan Susan | Zendy; Skudlarski Pawel | Zendy; Innis Robert B. | Zendy; Gore John C. | Zendy

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Functional magnetic resonance imaging of median nerve stimulation in rats at 2.0 T

Author(s) -

Scanley B. Ellen,

Kennan Richard P.,

Cannan Susan,

Skudlarski Pawel,

Innis Robert B.,

Gore John C.

Publication year - 1997

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.1910370625

Subject(s) - functional magnetic resonance imaging , propofol , stimulation , magnetic resonance imaging , anesthetic , median nerve , medicine , anesthesia , neuroscience , nuclear magnetic resonance , nuclear medicine , psychology , anatomy , radiology , physics

An animal model of sensory activation using fMRI at 2.0 T has been developed, demonstrating that fMRI studies on animals need not be limited to high field magnets. These methods produced reliable image intensity changes of 2% using median nerve stimulation in rats at 3 Hz and propofol as the anesthetic agent. At 6 Hz the activation was slightly but not statistically significantly greater. The feasibility of fMRI studies in animals using propofol suggests that it may be a useful anesthetic for fMRI studies in agitated adult patients or in children.

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