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A flexible magnetization transfer line shape derived from tissue experimental data
Author(s) -
Li Jonathan G.,
Graham Simon J.,
Henkelman R. Mark
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370610
Subject(s) - magnetization , magnetization transfer , line (geometry) , transfer (computing) , experimental data , materials science , biological system , physics , nuclear magnetic resonance , statistical physics , computer science , magnetic field , mathematics , biology , geometry , statistics , magnetic resonance imaging , medicine , quantum mechanics , parallel computing , radiology
To summarize and compare magnetization transfer data from biological tissues, a method was developed to extract the average absorption lineshape of the semi‐solid pool directly from magnetization transfer experimental data along with the four other parameters that characterize the two‐pool model of exchange. Magnetization transfer data for several biological tissues were analyzed using this method and the resulting “flexible” lineshapes were compared with super‐Lorentzian and “Kubo‐Tomita” lineshapes. The use of flexible lineshapes noticeably improves the fit of the two‐pool model to the data. The derived flexible lineshapes of all the tissues analyzed are physically realistic and show remarkably consistent behavior.