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In vivo measurement of regional brain metabolic response to hyperventilation using magnetic resonance: Proton echo planar spectroscopic imaging (PEPSI)
Author(s) -
Posse Stefan,
Dager Stephen R.,
Richards Todd L.,
Yuan Chun,
Ogg Robert,
Artru Alan A.,
MüllerGärtner HansWilhelm,
Hayes Cecil
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370609
Subject(s) - hyperventilation , normocapnia , nuclear medicine , magnetic resonance imaging , nuclear magnetic resonance , magnetic resonance spectroscopic imaging , voxel , chemistry , insular cortex , medicine , anatomy , radiology , physics , respiratory system , hypercapnia , psychiatry
A new rapid spectroscopic imaging technique with improved sensitivity and lipid suppression, referred to as Proton Echo Planar Spectroscopic Imaging (PEPSI), has been developed to measure the 2‐dimensional distribution of brain lactate increases during hyperventilation on a conventional clincal scanner equipped with a head surface coil phased array. PEPSI images (nominal voxel size: 1.125 cm 3 ) in five healthy subjects from an axial section approximately 20 mm inferior to the intercommissural line were obtained during an 8.5‐min baseline period of normocapnia and during the final 8.5 min of a 10‐min period of capnometry‐controlled hyperventilation (end‐tidal PCO 2 of 20 mmHg). The lactate/N‐acetyl aspartate signal increased significantly from baseline during hyperventilation for the insular cortex, temporal cortex, and occipital regions of both the right and left hemispheres, but not in the basal ganglia. Regional or hemispheric right‐to‐left differences were not found. The study extends previous work using single‐voxel MR spectroscopy to dynamically study hyperventilation effects on brain metabolism.