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3D localized in vivo 1 H spectroscopy of human brain by using a hybrid of 1D‐hadamard with 2D‐chemical shift imaging
Author(s) -
Gonen Oded,
AriasMendoza Fernando,
Goelman Gadi
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370503
Subject(s) - hadamard transform , spins , nuclear magnetic resonance , spectroscopy , voxel , interleaving , flip angle , quadrupole , physics , optics , chemistry , computer science , magnetic resonance imaging , artificial intelligence , atomic physics , medicine , quantum mechanics , radiology , condensed matter physics , operating system
We report acquisition of 3D image‐guided localized proton spectroscopy ( 1 H‐MRS) in the human brain on a standard clinical imager. 3D coverage is achieved with a hybrid of chemical shift imaging (CSI) and transverse Hadamard spectroscopic imaging (HSI). 16 × 16 × 4 arrays of 3.5 and 1 ml voxels were obtained in 27 min. The spatially selective HSI 90° pulses incorporate naturally into a PRESS double spin‐echo sequence to subdivide the VOI into four partitions along its short axis. 2D CSI (16 × 16) is performed along the other long axes. Because the hybrid excites the spins in the entire VOI, a √ N signal‐to‐noise‐ratio (SNR) gain per given examination time is realized compared with sequentially interleaving N 2D slices. A two‐fold gain in sensitivity is demonstrated in the brain for N = 4.