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Detection of glutamate/glutamine resonances by 1 H magnetic resonance spectroscopy at 0.5 tesla
Author(s) -
Prost Robert W.,
Mark Leighton,
Mewissen Mark,
Li ShiJiang
Publication year - 1997
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910370422
Subject(s) - nuclear magnetic resonance , glutamine , glutamate receptor , spectroscopy , chemistry , nuclear magnetic resonance spectroscopy , resonance (particle physics) , proton , analytical chemistry (journal) , physics , biochemistry , amino acid , atomic physics , receptor , quantum mechanics , chromatography
Midfield proton magnetic resonance spectroscopy (MRS) provides a noninvasive method to monitor glutamate and glutamine (Glx) levels in vivo . Experiments to detect the γ and β resonances of Glx have been performed by using commercial 0.5 T and 1.5 T MR scanners on seven patients with elevated blood ammonia and eight normal volunteers. Compared with the spectral sensitivity obtained on an otherwise identical system operating at 1.5 T, the singlet resonance of N ‐acetyl aspartate (NAA) was decreased by a factor of 1.48, which is significantly less than expected using the ratio of Boltzman populations at the two field strengths. However, the resonances of Glx at 0.5 T increased in signal‐to‐noise ratio (SNR) by a factor of 2. The increased SNR of Glx is principally due to improved B 0 main‐field homogeneity and collapse of the strongly J ‐coupled Glx resonances. Our preliminary results suggest that midfield proton MRS will provide significant clinical utility in the detection of Glx levels in human brain.